Deflanil® Plus is a food supplement based on Quercetin, Resveratrol, Bromelain, Hesperidin, Folic Acid, Vitamin C and Vitamin E.
Vitamin C contributes to the formation of collagen for the normal function of blood vessels.
Vitamin E contributes to the protection of cells from oxidative stress.
Folic acid (vitamin B9) contributes to normal homocysteine metabolism. A lack of this vitamin can cause homocysteine to accumulate, damaging the blood vessel walls. When the plasma levels of homocysteine reach too high concentrations, or exceed the value of 12 µmol / L, it is called hyperhomocysteinemia. In fact, high levels of this amino acid negatively affect the functions of the nervous, cardiovascular and bone systems, particularly through an increase in the production of free radicals and the oxidative stress that follows from this.
Bromelain is a complex of two proteolytic enzymes (able to degrade other proteins in amino acids) identified in Ananas comosus (Bromeliaceae family, hence the name). It is particularly used in the treatment of inflammatory states of soft tissues associated with trauma, in localized inflammations (especially in the presence of edema) and in postoperative tissue reactions. The safety of the use of bromelain compared to other anti-inflammatories, derives from the difference in its mechanism of action: in fact, where NSAIDs inhibit cyclooxygenase, blocking the synthesis of prostaglandins, bromelain, instead, increases the production of prostaglandins with anti-inflammatory activity detrimental to those with pro-inflammatory activity: thus the gastrointestinal damage typical of NSAIDs is avoided.
Resveratrol is a substance produced by different plant species which, thanks to its marked antioxidant properties, helps protect our body from cardiovascular diseases. It is a polyphenolic substance that is particularly active in protecting the microcirculation from damage caused by the formation of free radicals. This molecule also has anti-inflammatory and anticancer activity.
Quercetin is a flavonoid widely found in plants and marketed as a supplement. Quercetin is found abundantly in fruit and vegetables and has been shown to possess anti-inflammatory and antioxidant properties. It is one of the most common flavonoids as it can be isolated from numerous plant species including: horse chestnut, calendula, chamomile, hawthorn, hypericum, Ginkgo. It is considered a natural inhibitor of various intracellular enzymes:
-tyrosin kinase (TK), including epidermal growth factor receptor (EGFR) ;;
-5-lipoxygenase (which produces leukotrienes, mediators of asthma inflammation);
- phospholipase A2, which degrades membrane lipids, generating arachidonic acid which is then transformed into prostaglandins, involved in inflammation;
- ornithine decarboxylase (ODC) which produces polyamines, notoriously involved in cell proliferation;
- the phosphoinositide kinases PI3K and PI4P-5K, involved in proliferative responses triggered by the mitogenic pathways of signal translation.
For these properties it has been extensively studied in the experimental oncological field, in the elucidation of the mechanisms of cell proliferation and carcinogenesis.
Quercetin is a natural antioxidant. Among its most important functions are:
- restore tocopherol (Vitamin E), after it has turned into a free radical (tocopheryl-radical);
- "detoxify" the cell from superoxide anions;
- slow down the production of nitric oxide (NO) during inflammation.
Esperidine, a flavonoid characteristic of citrus fruits, is made up of a sugary part, the disaccharide rutinosio, linked to the flavone esperitin. Hesperidin possesses a marked antioxidant, capillarotropic and vasoprotective activity, which has facilitated its diffusion on the market as a vasoprotective agent. Hesperidin is used as such in the pharmaceutical field; we find it for example in DAFLON®, indicated as an adjuvant therapy in the treatment of varicose veins, of phlebitic complications of hemorrhoids and of those related to states of capillary fragility. In fact, Esperidin is widely known for its capillarotropic effects: it reduces the permeability and fragility of capillary walls, while it increases its resistance; in this sense, it shares the action of other vegetable substances, such as diosmin, escin, rutin, horse chestnut extracts, red vine, sweet clover, centella asiatica and bilberry. At the same time, Esperidin has remarkable antioxidant and anti-inflammatory properties.
* Note Values calculated on a single administration