Each sachet of Dolatrox contains MSM, ASI, SAMe, Vitamin C, Copper and Manganese chelates.
It is an organosulfuric compound source of sulfur, one of the main minerals of the cartilaginous tissue present in rather high concentration in the joints where it participates in different functions.
ASI (unsaponifiables of soya and avocado)
Based on the studies carried out, the ASI has proved to be active in stimulating collagen synthesis and slowing down the degradation process of the cartilage matrix.
S-adenosyl-L-Methionine (known as SAMe) is a coenzyme involved in the synthesis of neurotransmitters such as serotonin and dopamine, related to mood and pain threshold.
C vitamin is a water-soluble vitamin whose main role is antioxidant. It is essential for the formation of collagen, a protein necessary for the construction of connective tissue, ligaments and bones. It helps to maintain the normal functionality of cartilages.
CHISED BISGLICINATED COPPER
Copper is an essential microelement and, although its concentration within our organism is minimal, it intervenes in many vital processes of the human body. It becomes part of the structure of many enzymes in which it acts as a catalyst (ie it favors the carrying out of biochemical reactions). Copper contributes to the maintenance of connective tissues, the protection of cells from oxidative stress and the proper functioning of the immune system.
CHISED BISGLICINATED MANGANESE
Manganese, like copper, intervenes in the formation of connective tissues and contributes to the protection of cells from oxidative stress. Manganese is an important mineral for bone formation.
Chelation applied to both minerals greatly favors its absorption.
* Note Values calculated on a single administration
Osteoarthritis is a progressive disease that is widespread both by men and by the breakdown of articular cartilage and subchondral bone associated with changes in the synovial fluid. They are affected by the most kneeling and hip disease.
Experts from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) have gathered their experiences for slow-acting symptomatic drugs in osteoarthritis (SYSADOA) on the GRADE system. The acronym of GRADE stands for Grading of Recomendations Assessment, Devolpment and Evaluation; the system is based on a sequential assessment of the quality of the evidence, compared to the evaluation of the balance between benefits and votes.
We also focused on the use of the unsaponifiable soya-avocado fraction and on the use of sulfur-based compounds. This was found to be a reduction in pain and an improvement in physical function with a very low degree of toxicity.
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According to studies conducted by Blaine A. Christiansen et al., ASI (unsaponifiable fraction of soy and avocado) would seem to modulate the pathogenesis of osteoarthritis, inhibiting a large number of molecules and pathways in the same pathology.
These compounds showed anticatabolic and anabolic properties. Through the former they prevent cartilage degradation by inhibiting the release and activity of matrix metalloproteinases. Through the latter, instead, they promote cartilage repair, stimulating the synthesis of collagen and inhibiting pro-inflammatory cytokines such as interleukin 1, 6 and 8, TNF, ERK and prostaglandin E2. The chondroprotective effects are considered to increase the TGF-beta and to reduce the levels of VEGF (endothelial growth factor) in the synovial fluid.