The peripheral nervous system has the task of transporting information coming from the outside of our body up to the internal higher centers. It also controls skeletal muscles and muscle tissue. Its simple but vital role in connecting the central nervous system to the external environment can be undermined by various pathologies. There are many possible causes of peripheral nerve disorders; they can be framed on the basis of some characteristics regarding the mode of onset, the type of fiber involved, the distribution of pain and the type of "damage" that sustains them. Hereditary and metabolic factors, oxidative stress on nervous tissue, trauma and inflammation are hypothesized. Contributing to the proper functioning of the nervous system is important, also through food integration.
Using Xinepa® it is possible to favor the course of peripheral neuropathies in a positive way thanks to its special formulation:
Alpha-lipoic acid is present in our body. It possesses the ability to act in both water-soluble and fatty environments, and this very important property causes alpha-lipoic acid to have access to all cells in the human body. It is an antioxidant compound that plays an important role in the energy metabolism of cells. The synthesis of alpha lipoic acid by the body decreases with age. According to some studies it has been seen that this molecule has antioxidant properties and is able to reduce neuronal sensitivity to pain through the inhibition of T-type calcium channels.
N-acetyl-L-carnitine is present in skeletal muscles and striated muscles. Promotes the transport and consumption (oxidation) of long-chain fatty acids for energy production. According to some studies it has been seen that this molecule increases the regeneration of peripheral nerves.
Both alpha-lipoic acid and N-acetyl-L-carnitine in Xinepa® are characterized by an innovative technology that allows a modified release.
CURCUMA (95% titre in curcumin)
The BCM-95® turmeric extract is a turmeric extract (Curcuma longa L.) standardized to 95% in curcuminoids and essential oils naturally present in the rhizome of the plant. This particular combination increases its absorption after oral administration, optimizing the effects even at low dosage. In addition to its antioxidant action at the cellular level, curcumin has long been the subject of many clinical studies, as it is considered a potential agent for the treatment of certain inflammatory forms. It acts at the level of COX (cyclooxygenase) and LOX (lipoxygenase), two enzymes that act as chemical mediators in inflammatory processes.
VITAMINS OF GROUP B: B1 + B2 + B6 + B12
The B vitamins have an energetic, neuroprotective and metabolic effect. They therefore contribute to the normal functioning of the nervous system and energy metabolism. Vitamins B1 and B2 provide energy to the nervous tissue. Vitamin B6 is essential for the synthesis of neurotransmitters (including serotonin that has positive effects on mood) and for the formation of myelin, a structure that acts as a protection for the central nervous system.
Vitamin B12 is necessary for the proper formation of red blood cells and for maintaining the integrity and functionality of the myelin sheath.
In fact, its deficiency leads to an altered biosynthesis of fatty acids which are a structural part of the myelin coating. Vitamins B2 and B6 also represent a valuable aid to contribute to the reduction of tiredness and fatigue.
Liposoluble antioxidant par excellence, at the level of cell membranes protects the cell from the damage induced by free radicals. It helps to keep the nervous system in good condition, protecting blood vessels and nerve cell membranes.
Vitamin C is a water-soluble antioxidant and its integration is particularly effective when combined with vitamin E. It is a vitamin with multiple and recognized functions. It contributes to the protection of cells from oxidative stress, the functioning of the nervous system and psychological well-being. Reduces tiredness and fatigue, and helps the functionality of the immune system.
* Note Values calculated on a single administration
A study has been carried out on Xinepa that demonstrates the efficacy of its constituents in osteo-articular pathologies, and in particular, in carpal tunnel syndrome.
Patients with this syndrome were given the supplement twice a day for a period of one month.
This treatment has also been associated with therapy with low-frequency magnetic fields; the latter are able to act on the C fibers, in particular on the "inward rectifying" potassium channels.
Nutraceuticals based on alpha lipoic acid, curcumin, group D vitamins and acetyl-L-carnitine have significant anti-inflammatory, antioxidant and neuroprotective effects on peripheral nerves. Acetyl-L-carnitine stimulates the regeneration of peripheral nerves; the alpha lipoic acid, thanks to its antioxidant activity, reduces the neuronal sensitivity towards pain stimuli, inhibiting the T-type calcium channels and also stimulates the conduction of motor nerves; curcumin has antinociceptive properties, but also an anti-inflammatory action, as it inhibits the production of numerous inflammation mediators; the B-group vitamins in high doses would seem to result in reduced pain, numbness, and paresthesia.
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