NFF ™ (Neurotrificing Functioning Factor), is a multi-phase dietary supplement formulated in tablets based on functional neurotrophic ingredients useful to contribute to the proper functioning of peripheral neurotransmission, when their dietary intake is absent or lacking. Specifically, the ingredients perform the following actions:
- Vitamin B6 contributes to the normal functioning of the nervous system.
- Vitamin B12 intervenes in the process of cell division.
-The zinc contributes to the protection of fibroblasts (cells used to build nerve tissue) from oxidative stress.
-The quercetin is a flavonoid widely present in plants and marketed as a supplement. Quercetin is abundantly found in fruits and vegetables and has been shown to possess multiple forms of desirable biological activity including anti-inflammatory and antioxidant properties.
- Bromelain is a complex of two proteolytic enzymes (ie a protein capable of degrading other proteins in amino acids) identified in Ananas comosus (Bromeliaceae family from which the name). It is particularly used in the treatment of soft tissue inflammatory states associated with trauma, in localized inflammation (especially in the presence of edema), and in postoperative tissue reactions. The safety of the use of bromelain compared to other anti-inflammatories, derives from the difference in its mechanism of action: in fact, where NSAIDs inhibit the CyclOxygenase, blocking the synthesis of prostaglandins, Bromelain, instead, increases the production of prostaglandins with anti-inflammatory activity at detrimental to those with pro-inflammatory activity: this avoids the typical gastrointestinal damage of NSAIDs. The catalytic power of bromelain is expressed in GDU / g; the higher this value, the more potent the enzyme preparation is. In Biocartilago is present Bromelina 2500 GDU.
Below is a useful and explanatory link on the calculation and meaning of the GDU catalytic power:
https://liborioquinto.altervista.org/potenza-della-bromelina/
- Alpha-lipoic acid is present in our body. It has the ability to act in both water-soluble and fatty environments and this very important property causes alpha-lipoic acid to have access to all cells in the human body. It is an antioxidant compound that plays an important role in the energy metabolism of cells. The synthesis of alpha lipoic acid by the body decreases with age. According to some studies, this molecule has antioxidant properties and is able to reduce neuronal sensitivity to pain by inhibiting T-type calcium channels.
-N-acetyl-L-carnitine is present in skeletal muscles and striated muscles. Promotes the transport and consumption (oxidation) of long-chain fatty acids for energy production. According to some studies it has been seen that this molecule increases the regeneration of peripheral nerves.
The formula is completed by enriching and strengthening its antioxidant and joint support function, other components from the Ribolife ® free nucleotide mixture.
Nutrients (mg)
* Note Values calculated on a single administration
Several studies have reported the effect of quercetin on glial cells. Quercetin is a component extracted from various fruits and vegetables and exerts anti-inflammatory, analgesic, anti-cancer, anti-ulcer and antihypertensive effects. However, the exact mechanism underlying the analgesic action of quercetin remains poorly understood.
Several mechanisms have been proposed that explain how this compound can reduce neuropathic pain; in particular, the following study was carried out in a rat model with nerve injury. Pain behaviors on the hind leg and glial fibrillary acid (GFAP) levels in the dorsal root ganglion (DRG) and in the spinal cord were measured. Before surgery, 1% oral quercetin was given. It was observed that quercetin inhibited GFAP in the glial satellite cells of the ipsilateral L5 DRG compared to the control group. Quercetin suppressed the development of neuropathic pain through a mechanism involved in the inhibition of glial satellite cells. Because its safety is well established, it has great potential for clinical use in the treatment of pain.
https://www.ncbi.nlm.nih.gov/pubmed/30369602
Also in the field of diabetic pain, the action of quercetin was investigated; indeed, the upregulation of nociceptive ion channels expressed in the dorsal root ganglia (DRG) contributes to the development and maintenance of diabetic pain symptoms. The aim of this study was to study the effects of quercetin on P2X4 receptor-related diabetic neuropathic pain in rat type 2 diabetic rat model. The data demonstrate that quercetin can reduce the up-regulation of P2X4 receptor in satellite glial cells of DRG and inhibit P250 receptor-mediated p38MAPK activation to relieve mechanical and thermal hyperalgesia in diabetic rats.
