SAMe is a natural substance present in the body's cells. Comes from the combination of the essential amino acid L-methionine with adenosine-triphosphate (ATP). It has a crucial biochemical role in the body as it gives a methyl group in the biosynthesis of nucleic acids in both DNA and RNA, phospholipids, proteins, adrenaline, melatonin, creatinine and other molecules. It is also involved in the methylation of histones, the main structural elements of chromosomes. Any alteration in the availability of SAMe can have a profound impact on cell growth, differentiation and proliferation. It is what is called a pleiotropic molecule, as it is at the center of many different biological functions, but interconnected. For this reason the integration with SAMe finds space in many different situations. Many scientific evidence has shown that supplementation with S-adenosyl-methionine can have beneficial effects on the body. SAMe levels tend to decline significantly with advancing age and its deficiency also appears to characterize patients affected by mood changes. S-adenosyl-methionine is a molecule produced by the body that acts at the crossroads of over 100 biochemical processes. The integration with SAMe can be requested in all those states associated with reduced availability of SAMe.
Coenzyme Q10 belongs to a family of substances called ubiquinones, lipophilic compounds, insoluble in water involved in the transport of electrons and in the production of energy in the mitochondria. The head structure (benzoquinone) participates in the redox (antioxidant) activity of the electron transport chain. CoQ10 is synthesized by the body with a metabolism common to that of cholesterol. Its levels decrease with advancing age in humans, perhaps due to a decrease in its synthesis or due to the increase in lipid peroxidation which increases with age. An integration with the diet can compensate for this decrease.
* Note Values calculated on a single administration
Several studies have been performed on S-Adenosylmethionine (SAMe) to demonstrate that it has an antidepressant effect and may be beneficial for neuropsychiatric disorders.
SAMe is an endogenous, intracellular molecule, naturally produced by all the cells of our body, starting from ATP and the amino acid Methionine; it is also involved in various biochemical pathways, including those of the biosynthesis of hormones and neurotransmitters. SAMe levels are reduced in some conditions, including depression, Alzheimer's, Parkinson's, HIV. Most probably at the base of the reduced synthesis of SAMe, found in some of these pathologies, there is a deficiency of Folate and Vitamin B12 (essential cofactors for the biosynthesis of the molecule itself). In some experiments, it was found that SAMe, in a dose-dependent manner, increases the concentrations of monoamine neurotransmitters (Serotonin and Norepinephrine); moreover the administration of SAMe determines an increase of dopaminergic tone in some cerebral areas (striatum in particular) and increases both the density and the activity of beta adrenergic receptors. These studies, therefore, suggest that SAMe has antidepressant effects similar to those performed by common antidepressant drugs. In fact, in the synaptic vesicle of the hippocampus, SAMe promotes an increase in the protein kinase responsible for vesicular fusion and the release of neurotransmitters.