Gastroesophageal reflux is the return of part of the stomach contents to the esophagus. Under normal conditions, the food bolus passes from the esophagus to the stomach, but not vice versa due to the presence of the lower esophageal sphincter (LES, Lower Esophageal Sphincter) and of a pressure difference between esophagus and stomach of about 12 mmHg. Furthermore the esophagus is characterized by peristaltic waves that favor the flow of material towards the stomach. Gastroesophageal reflux becomes a disease (gastroesophageal reflux disease, GERD or GERD according to the English definition Gastroesophageal Reflux Disease) when it becomes chronic. The repeated return of the acidic contents of the stomach alters the esophagus mucosa causing erosions and ulcerations until serious complications such as esophagitis, Barrett's esophagus and adenocarcinoma of the distal esophagus appear.
Gastroesophageal reflux disease has a prevalence in the general population of 5-6%, the incidence increases in particular subgroups of people such as the elderly and pregnant women. In the latter, the pressure exerted by the fetus on the internal organs favors the appearance of gastroesophageal reflux.
Gastropiù buste is a supplement based on sodium alginate and hyaluronic acid. The combination of the ingredients is patented because the formation of the alginate polymer takes place thanks to this formulation.
In order for the barrier action of sodium alginate to be truly effective, the gelled alginate must position itself over the contents of the stomach to form a sort of "floating raft".
The method of administration of alginate is essential to obtain the barrier effect. For the alginate to be effectively effective it must be administered after meals. If administered on an empty stomach, the alginate concentrates at the base of the large curvature of the stomach, towards the lower part of the stomach, and in about 20 minutes the half of administered alginate is expelled.
Hyaluronic acid is one of the fundamental components of the human and mammalian connective. Thanks to its chemical structure, it has a high solubility in water. Thanks to this property, the hyaluronate is able to complex with many water molecules reaching a high degree of hydration, forming a gel. Hyaluronic acid also plays an important role in tissue repair and protection.
During the initial phase of inflammation, hyaluronic acid is secreted by the body as a natural response of the tissue against the harmful action of bacterial hyaluronidases and edema formation. Hyaluronic acid is an anti-inflammatory, anedemic and protective agent of the gastric and laryngeal-esophageal mucosa.
Alginates are neutral polysaccharide polymers isolated from brown algae (Phacophycae) and are classified as dietary fiber. They consist of a percentage of D-mannan L-glucuronic acids. In the presence of gastric acid, the alginates precipitate forming a gel, which tends to form a floating barrier on the mouth of the stomach. Clinical studies have shown that the pH of the barrier composed of alginate is neutral, while the gastric pH below the barrier is decidedly acidic. These studies show that with the presence of alginates an effective barrier is formed against gastric acidity; they also show that there is a rapid reduction in symptoms related to esophageal reflux. Recent studies have confirmed the effectiveness of alginates in reducing the symptoms related to esophageal reflux.
Pack of 20 sachets of 1 g
Water, Stabilizer: Xylitol, Sodium Alginate, Emulsifier: Citric esters of mono- and diglycerides of fatty acids, Preservatives: Sodium benzoate, Potassium sorbate, Sodium hyaluronate, Aroma, Sweetener, Sucralose.
* Note Values calculated on a single administration