REFEROL IMMUNO is a supplement based on Astragalus tit.4% Polysaccharides; Mixture of Lactobacilli (L.acidophilus SGL11 40%; L. rhamnosus SGL06 25%, B. Bifidum SGB02 25%; S. termophilus SGST01 7%; L. delbrueckii bulgaricus ATCC11842-7995 3%); Eleutherococcus tit. 0.4%; Echinacea purpurea (dry extract, whole root and top, tit.4% polyphenols); Polygonum cuspidatum root dry extract tit.98% resveratrol; Acerola tit.50% Vitamin C; Rosa Canina tit.70% Vitamin C.
The active ingredients of the plants included in Referol Immuno have important tonic-adaptogenic characteristics: they are able to provide the body with a better resistance against various factors that can characterize cooling and / or flu situations.
Astragalus is used as a natural remedy for colds and flu. The immunostimulant properties relating, in particular, to the polysaccharides and saponins present have been confirmed. The immunostimulatory activity of astragalus has been confirmed by several studies conducted on the subject, which showed that this action is carried out through different mechanisms, such as: the increase in the proliferation of B lymphocytes; increased synthesis of interleukins and tumor necrosis factor by macrophages and increased T lymphocyte activity.
Echinacea, thanks to its immunostimulant properties, is one of the most sought after medicinal plants in the Italian phytotherapeutic landscape. This plant is able to perform important antiviral actions. This characteristic is attributable both to the general immunostimulatory effect, and to its ability to inhibit the enzyme hyaluronidase which degrades hyaluronic acid in its fundamental constituents. In addition to being an essential nutrient for joint cartilage, this polysaccharide is part of the composition of connective tissue, which regulates permeability. Many pathogenic microorganisms contain large amounts of hyaluronidase. This facilitates its penetration into the tissues and, consequently, the pathogenic action. Echinacea, inactivating this enzyme, protects the body from certain viruses.
Acerola is a fruit rich in vitamin C and active ingredients that help fight flu and seasonal ailments. In particular, the Acerola stimulates the immune system, enhancing the action of antibodies. In this way it is able to prevent various types of colds, flu and infections. At a time when these ailments have already occurred, the Acerola is of great support in helping to heal faster, also avoiding possible relapses. In addition to the high amount of vitamin C, Acerola contains provitamin A, a good amount of vitamin B1, B2, B3, B5 and B6 and various mineral salts including calcium magnesium, potassium, iron, phosphorus.
Eleutherococcus is a shrub belonging to the Araliaceae family, approximately two meters high and originating from the north-eastern Asian regions. The active ingredients responsible for the health properties of eleuterococcus are concentrated in the root and belong mainly to the category of glycosides. It is an "adaptogenic" plant; plants that enjoy this phytotherapeutic property are useful mainly when the body's resistance is diminished or when it is undermined by excessive efforts. In practice, Eleuterococcus is able to increase the resistance and the body's defenses to stress factors in a non-specific way, counteracting general psycho-physical fatigue. This shrub favors the strengthening of the immune defenses, useful for reducing the incidence and complications related to the flu, protecting also from the episodes of reactivation of herpes simplex type II.
* Note Values calculated on a single administration
Numerous studies conducted in vivo on the single molecules contained in Referol Immuno have shown a remarkable immunostimulatory activity towards both the humoral and cell-mediated immune systems.
Oral administration of Astragalus performed on 1000 subjects was able to decrease the incidence and reduce the course of common colds. In these subjects, after two months of oral administration of extract, there was an increase in IgA and IgG levels. Based on in vivo, in vitro and clinical studies, the German Ministry of Health has included Echinacea root in positive monographs, with the indication "supportive therapy during flu-like viral infections".
Several studies show the anti-inflammatory efficacy of Resveratrol, but there is more: an all-Italian research, of La Sapienza University and Higher Institute of Health, has demonstrated the antiviral capacities of this molecule, while a study already published on "The Journal of lnfectious deseases" shows that resveratrol is able to protect against the human influenza virus, and this both in cell cultures and in vivo on animals. The biochemical mechanism through which this molecule performs the inhibition of the replication of Influenza A virus is well explained in the scientific article of which the link is reported: