Epi Brain, besides being useful to provide memory and cognitive functions, is indicated in all cases where a physiological support for mental exhaustion and difficulty in concentration and attention is necessary.
Epi Brain capsules contain Vitamin C, E, Niacin, Selenium, Vitamin A, Ginkgo biloba, L-Carnitine, Coenzyme Q10, Fish oil and Vitamin D3.
Vitamins C and E, Niacin and Selenium contribute to the protection of cells from oxidative stress and fatigue. Vitamin A is a support of normal visual ability.
Selenium, in particular, is an indispensable element for the glutathione peroxidase, which in turn works together with vitamin E to prevent damage caused by free radicals to cell membranes. In the product it is present in the form of selenium-methionine. The effectiveness is to protect the membranes from oxidation, selenium has a protective effect on the immune system. It also seems to play an antagonistic role towards heavy metals, such as mercury, cadmium and silver. Selenium is an essential component of the enzymatic system that transforms thyroxine (T4) into triiodothyronine (T3), and as a story plays a major role in supporting thyroid function.
Ginkgo biloba (leaves and 24% in ginkgoflavonoidi) is a plant of Chinese origin known since antiquity for its energetic and antioxidant properties. Today it is one of the most used and esteemed natural supplements to strengthen memory and stimulate concentration. Many properties are attributed to ginkgo, among which, certainly, antioxidants stand out. This activity is attributable to flavonoids and terpenic derivatives (ginkgolides and sesquiterpene lactones) contained therein. These molecules, in addition to counteracting lipid peroxidation, also explain the behavior of "scavengers" of free radicals.
Coenzyme Q10, also called "ubiquinone", is a ubiquitous molecule, mainly involved in the cellular respiration process; in fact, it is found in cell membranes and in mitochondria. Coenzyme Q10 intervenes in chemical reactions within adenosine triphosphate molecules (ATP), so that it is stored ready to use.
Vitamin D3 (or cholecalciferol) is the most important of the five forms of vitamin D; is able to promote intestinal absorption of calcium and phosphorus; it is important for the development of bones and keratinocytes. He passed the examination of bone metabolism and muscle function, both for extra-skeletal actions; the latter involve the immune system, the processes of apoptosis and carcinogenesis, the cardiovascular system, glucose metabolism, but above all nervous system, expounding neuroprotective functions.
L-Carnitine is an amino acid derivative synthesized in the human body, mainly in the hepatic and renal levels. Said more simply Carnitine, it is synthesized starting from two amino acids in the presence of Niacin, Vitamin B6, Vitamin C and iron. The best known activity of Carnitine is its role as a transporter of fatty acids in mitochondrial conversion, where fatty acids are converted into energy through the process of Beta-oxidation. The molecule is similar, from a structural point of view, to the neurotransmitter Acetylcholine; the hypothesis has been proposed that Carnitine can play a fundamental role for the chemical mediator.
The omega-3 (EPA and DHA) contained in Fish oil (65% powder titrated to 40% in EPA and 20% DHA) play a key role in the brain functions of man; in fact, integration is often undertaken in the neurological field, not only as an adjuvant to the normal therapies available for important diseases such as Alzheimer's, but also to slow down cognitive aging and preserve the function of memory over the years. Not to be underestimated their immunomodulatory action, fundamental given the increase in the incidence of autoimmune diseases. They also have an anti-inflammatory function, which inhibits the production of inflammation mediators, such as prostaglandins and leukotrienes.
* Note Values calculated on a single administration
Several studies have highlighted the role of Ginkgo biloba in diseases affecting the nervous system. In particular, it has been shown that, by administering the extract of this plant, a protective role is obtained on the neuropsychiatric symptoms typical of Alzheimer's disease.
The experiments were carried out on patients presenting with medium to moderate dementia and, indeed, it was found that on some symptoms such as depression/dysphoria, agitation/aggression, apathy, anxiety, irritability there was a benefit.
Moreover, Ginkgo's capacity to strengthen memory is of fundamental importance, since it is able to reduce oxidative stress in the hippocampus, which is one of the brain areas most often involved in neurodegenerative diseases. The precise mechanism through which it is able to do this, has not yet been fully clarified; however, various hypotheses have been proposed, including:
- the ability of the Ginkgo extract to increase the expression of brain neurotrophins which, in turn, increase, among other things, the resistance of neurons to ischemic damage;
- reduction of glutamate release and increase of its uptake;
-the increase in the biogenesis of mitochondria in the brain;
-the increase in the expression of enzymes with an anti-oxidant function.