Biocartilago ™ is a multi-phase dietary supplement formulated in sachets based on functional ingredients useful when their dietary intake is absent or lacking.
In particular, the ingredients perform the following actions.
-Vitamin B6 contributes to normal energy metabolism.
-Vitamin B12 intervenes in the process of cell division.
-Zinc contributes to the protection of fibroblasts (cells used to build nerve tissue) from oxidative stress.
-Chondroitin and glucosamine sulfate are two substances naturally present in the connective tissues of the human body, especially at the level of cartilages. Chondroitin sulfate is an important structural component of cartilage, responsible for almost all cartilage compression resistance. Glucosamine is an aminomonosaccharide (or glycosamine) and one of the main precursors of the synthesis of glycosylated proteins and lipids. It is one of the major components of the shell of crustaceans and other arthropods, in mushrooms and many higher organisms.
-Bromelain is a complex of two proteolytic enzymes (ie a protein capable of degrading other proteins in amino acids) identified in Ananas comosus (Bromeliaceae family from which the name). It is particularly used in the treatment of soft tissue inflammatory states associated with trauma, in localized inflammation (especially in the presence of edema), and in postoperative tissue reactions. The safety of the use of bromelain compared to other anti-inflammatories, derives from the difference in its mechanism of action: in fact, where NSAIDs inhibit the CyclOxygenase, blocking the synthesis of prostaglandins, Bromelain, instead, increases the production of prostaglandins with anti-inflammatory activity at detrimental to those with pro-inflammatory activity: this avoids the typical gastrointestinal damage of NSAIDs. The catalytic power of bromelain is expressed in GDU / g; the higher this value, the more potent the enzyme preparation is. In Biocartilago is present Bromelina 2500 GDU.
Below is a useful and explanatory link on the calculation and meaning of the GDU catalytic power:
-Methylsulfonylmethane (MSM) is a direct donor of biologically active sulfur. Methylsulfonylmethane has a high gastric tolerability. This compound has chondroprotective properties: stimulating the synthesis of articular cartilage, p able to increase the mobility of the arthritic joint, inhibiting further cartilage damage.
-Turmeric (present as dry extract) has long been known for its anti-inflammatory properties; the main component of the extract, curcumin, is a polyphenol able to act on the differentiation of osteoclasts useful for the treatment of osteoporosis as it seems to act on the Wnt / β-catenin pathway, an important signaling pathway because involved in the growth, in the development and maintenance of a number of tissues, including bone tissue.
-Collagen is the main protein in the connective tissue of our body; there are many different types of collagen in our body and their absence causes major dysfunctions. The lack of production of type 1 collagen, for example, results in extremely fragile bones. Long-chain proteins, such as collagen, are distributed during digestion in their original amino acids and can then be absorbed. Once absorbed, these amino acids may represent the necessary source for the synthesis of collagen throughout the body. If administered orally, it stimulates a statistically significant increase in the synthesis of macromolecules of the extracellular matrix by chondrocytes. These results suggest that collagen-based supplements could actually help patients with common and widespread diseases such as osteoarthritis. Numerous studies have also shown that collagen is an effective source of joint pain improvement in women and men affected by osteoarthritis, osteoarthritis and similar clinical conditions.
-Quercetin is a flavonoid widely present in plants and marketed as a supplement. Quercetin is abundantly found in fruits and vegetables and has been shown to possess multiple forms of desirable biological activity including anti-inflammatory and antioxidant properties.
* Note Values calculated on a single administration
A double-blind controlled study demonstrates the efficacy of chondroitin sulfate, quercetin and glucosamine: 40 patients with symptomatic knee osteoarthritis (gonarthrosis) were given orally a product containing glucosamine hydrochloride, chondroitin sulphate and quercetin. After four months of treatment, a significant clinical improvement was observed in the subjects treated with the product compared to the placebo group, in terms of increased ambulatory capacity and reduction of joint pain, the latter assessed on the basis of a scale developed by the JOA, the Society of Japanese Orthopedic.
The clinical data are then corroborated by the finding of an improvement trend also in the cartilage metabolic markers, as well as a normalization of specific biochemical parameters of the synovial fluid, with a reduction in the levels of proteins and chondroitin sulphate type 6, and increase in the molecular weight of hyaluronic acid.
The data is important because it clearly supports the usefulness of a global approach to arthritis: that approach, that is, which makes use of not only substances classically aimed at protecting cartilage (chondroitin sulfate and glucosamine), but also other (such as quercetin) capable of counteracting different pathological processes and concomitant to chondrodegeneration, such as inflammation and endoarticular oxidative stress.