SAMe is a natural substance present in the body's cells. It derives from the combination of the essential amino acid L-methionine with adenosine-triphosphate (ATP). It has a crucial biochemical role in the body as it gives a methyl group in the biosynthesis of nucleic acids of both DNA and RNA, phospholipids, proteins, adrenaline, melatonin, creatinine and other molecules. The main structural elements of chromosomes are also involved in histone methylation.
Any alteration in the availability of SAMe can have a profound impact on cell growth, differentiation and proliferation. It is what is called a pleiotropic molecule, as it is at the center of many different but interconnected biological functions. For this reason the integration with SAMe finds space in many different situations.
Many scientific evidences have shown how the supplementation of S-adenosyl-methionine can have beneficial effects on the body. SAMe levels tend to decrease significantly with advancing age, and its deficiency also appears to characterize patients with altered mood. S-adenosyl-methionine is a molecule produced by the body that acts at the crossroads of over 100 biochemical processes. Integration with SAMe may be required in all those states associated with reduced SAMe availability.
Betaine is a natural substance extracted from sugar beet (Beta vulgaris), to which it owes its name. Also known as trimethylglycine, Betaine is a known methylating agent; this means that it has the ability to yield methyl groups (CH3) to various substances.
Due to this activity, Betaine has been successfully used in the treatment of homocystinuria and hyperhomocysteinemia, conditions associated with an increased cardiovascular risk. In addition to the detoxifying activity with respect to homocysteine, widely described in the previous paragraph, Betaine has shown during the studies, especially experimental ones, other interesting activities.
More precisely, Betaine would seem:
-Exercise a hepatoprotective action against environmental intoxicants;
- Exercise a lipotropic action (useful activity in preventing and accelerating the removal of deposited fat) against the fatty liver (steatosic);
- Exercise a mild antidepressant action, since it can be converted into S-adenosylmethionine, a substance with non-specific antidepressant effects;
-Exercise a neuroprotective action against alcohol-induced damage;
- Exercise a potential slimming activity.
* Note Values calculated on a single administration