Deflanil® is a gel based on Bromelain, Escin and flavonoids, including Quercetin, Esperidin and Vitis vinifera, functional substances that aid treatments that aim to reactivate the circulation. It helps to relieve the annoying sensations of swelling, itching, heaviness and tension of the limbs. The natural active ingredients contained in Deflanil® gel are useful to improve the circulation of the legs, restoring the physiological permeability and the normal tone of the veins.
Bromelain is a complex of two proteolytic enzymes (able to degrade other proteins in amino acids) identified in Ananas comosus (Bromeliaceae family, hence the name). It is particularly used in the treatment of inflammatory states of soft tissues associated with trauma, in localized inflammations (especially in the presence of edema) and in postoperative tissue reactions. The safety of the use of bromelain compared to other anti-inflammatories, derives from the difference in its mechanism of action: in fact, where NSAIDs inhibit cyclooxygenase, blocking the synthesis of prostaglandins, bromelain, instead, increases the production of prostaglandins with anti-inflammatory activity detrimental to those with pro-inflammatory activity: thus the gastrointestinal damage typical of NSAIDs is avoided.
Quercetin is a flavonoid widely found in plants and marketed as a supplement. Quercetin is found abundantly in fruit and vegetables and has been shown to possess anti-inflammatory and antioxidant properties. It is one of the most common flavonoids as it can be isolated from numerous plant species including: horse chestnut, calendula, chamomile, hawthorn, hypericum, Ginkgo. It is considered a natural inhibitor of various intracellular enzymes, among which:
-tyrosin kinase (TK), including the epidermal growth factor receptor (EGFR);
-5-lipoxygenase (which produces leukotrienes, mediators of asthma inflammation);
- phospholipase A2, which degrades membrane lipids, generating arachidonic acid which is then transformed into prostaglandins, involved in inflammation;
- ornithine decarboxylase (ODC) which produces polyamines, notoriously involved in cell proliferation;
- the phosphoinositide kinases PI3K and PI4P-5K, involved in proliferative responses triggered by the mitogenic pathways of signal translation.
For these properties it has been extensively studied in the experimental oncological field, in the elucidation of the mechanisms of cell proliferation and carcinogenesis.
Quercetin is a natural antioxidant. Among its most important functions are:
- restore tocopherol (Vitamin E), after it has turned into a free radical (tocopheryl-radical);
- "detoxify" the cell from superoxide anions;
- slow down the production of nitric oxide (NO) during inflammation.
Esperidine, a flavonoid characteristic of citrus fruits, is made up of a sugary part, the disaccharide rutinosio, linked to the flavone esperitin. Hesperidin possesses a marked antioxidant, capillarotropic and vasoprotective activity, which has facilitated its diffusion on the market as a vasoprotective agent. Hesperidin is used as such in the pharmaceutical field; we find it for example in DAFLON®, indicated as an adjuvant therapy in the treatment of varicose veins, of phlebitic complications of hemorrhoids and of those related to states of capillary fragility. In fact, Esperidin is widely known for its capillarotropic effects: it reduces the permeability and fragility of capillary walls, while it increases its resistance; in this sense, it shares the action of other vegetable substances, such as diosmin, escin, rutin, horse chestnut extracts, red vine, sweet clover, centella asiatica and bilberry. At the same time, Esperidin has remarkable antioxidant and anti-inflammatory properties.
Escin is the mixture of saponins extractable from seeds (13%), bark (1%) and leaves (0.2%) of horse chestnut, to which it gives the known medicinal properties. In fact, it is used for external (important massage) or internal use, in the treatment of various types of edema, varicose veins, hemorrhoids, cellulite, bruises and bruises, thanks to its ability to increase capillary resistance and reduce permeability. Escin is also indicated in the presence of chronic venous insufficiency, thanks to its anti-inflammatory and venotonic effects (it increases venous contractility, reducing blood stagnation in the lower limbs and favoring its return to the heart).
Some clinical studies have shown that the extract of vine seeds (Vitis vinifera) is particularly effective in countering peripheral venous insufficiency and the symptoms associated with it, such as swelling and feeling of heavy legs. This plant, rich in bioflavonoids, seems to be able to activate microcirculation, facilitating the drainage of liquids.
Deflanil® gel is presented in a 125 ml tube.
