N-acetylcysteine is a fluidifier of bronchial secretions able to help the respiratory system to protect itself from external insults of various kinds such as viruses / bacteria, cigarette smoke, pollution. Acetylcysteine is a mucolytic derived from an amino acid "sulfurate", cysteine. The activity of acetylcysteine on the mucous component of the secretions is due to the presence in the molecule of a free thiol group (-SH), able to reduce and break down the disulfide bridges (-SS-) responsible for the aggregation of proteins and therefore of the high viscosity of the mucus.
Lactoferrin is a globular protein that presents antimicrobial activity, normally present in saliva that can be useful to favor natural defenses; the antimicrobial properties of lactoferrin are mainly due to the ability to bind iron, removing it from the metabolism of those bacterial species (such as Escherichia coli), which depend on it for its multiplication and adhesion to the mucosa (bacteriostatic effect); it also has a direct antibacterial (bactericidal) action, thanks to the ability to damage the outer layers of the cell membrane of some negative GRAM bacterial species.
Polygonum cuspidatum, (98% extract of Resveratrol) has antioxidant and fluidifying properties of bronchial secretions. Resveratrol, natural polyphenol, inhibits the replication of rhinovirus, influenza virus and respiratory syncytial virus (Vrs). Moreover it drastically reduces the synthesis of proinflammatory molecules induced by the infection (interleucihina-6 and 8, Rantes), which are the main responsible of the symptoms associated with viral infections of the upper respiratory tract.
* Note Values calculated on a single administration