BPF (Bergamot Polyphenolic Fraction) is a standardized extract of bergamot juice. Bergamot juice is characterized by a unique profile of flavonoids such as neoeriocitrina, neoesperidine and, as recently discovered, brutieridine and melitidine. Thanks to the combined action of flavonoids, bergamot juice has shown a marked activity in metabolic syndromes, in reducing cardiovascular risk, in regulating circulating cholesterol and in controlling glycemia and triglycerides. Flavonoids extracted from this citrus fruit:
1. Inhibit the activity of the enzyme HMG-CoA reductase, a key enzyme of cholesterol biosynthesis and target of statins;
2. Reduce the release of the LDL (low-density lipoprotein, the so-called "bad cholesterol") in the liver through the inhibition of ACAT acyltransferase;
3. Increases the biliary excretion of cholesterol;
4. Help reduce levels of triglycerides by inhibiting the enzyme PAP (hepatic microsomal phosphatidate phosphohydrolase) involved in their synthesis;
5. Help reduce blood glucose levels by increasing glucose uptake from the liver and peripheral tissues (muscle cells);
6. Reduce blood levels of uric acid.
L-ascorbic acid or vitamin C, is an organic compound found in nature with antioxidant properties. Vitamin C is important for the proper functioning of the immune system and the synthesis of collagen in the body. Collagen strengthens blood vessels, skin, muscles and bones. It increases the body's resistance, strengthens the function of phagocytes, increases the production of antibodies, stimulates the synthesis of interferon, the biosynthesis of carnitine, contributes to the oxidation of free radicals. Vitamin C contributes to the protection of cells from oxidative stress.
Zinc is a fundamental element for the correct functioning of numerous enzymatic functions. It is also essential for the functioning of the immune system, it acts on the mediators of the immune response (peptides and cytokines). It is also a mineral that contributes to the normal metabolism of fatty acids.
* Note Values calculated on a single administration
Some patients with dyslipidemia have important side effects induced by the statins with which they are in therapy and would prefer a nutraceutical approach. This has stimulated research for alternative therapeutic approaches for the management of dyslipidemia. In recent studies, in particular, it has been shown that bergamia citrus juice (known as bergamot) was able to reduce serum lipid levels.
These benefits can be attributed to large amounts of flavonoids contained in the juice of the bergamot fruit (neoeriocitrina, neoesperidina, naringina). The aim of the present study was to investigate the effects of a bergamot extract on cardio-metabolic parameters, including plasma lipids, atherogenic lipoproteins and subclinical atherosclerosis.
This is the first study that studies the effects of bergamot flavonoids. Integration with BergavitR (bergamot juice) significantly reduced plasma lipids and improved the lipoprotein profile.
After 6 months of treatment with BergavitR the lipid levels of integration (TC, TG and LDL-C) decreased, while the atherogenic lipid pattern improved with a good reduction of the LDL-circulating cholesterol.