Cardiol Forte is formulated with fish oil rich in omega-3 EPA and DHA, monacolin K (derived from fermented red rice), olive polyphenols, coenzyme Q10 and vitamins.
The omega-3 fatty acids EPA and DHA support normal cardiac function with a minimum daily intake of 250 mg; this quantity is approved by Regulation 432/2012 of the European Commission. One capsule of Cardiol® Forte provides approximately 350 mg of EPA + DHA.
Monacolin K is the most important component of fermented red rice. The daily intake of 10 mg of monacolin K contributes to the maintenance of normal levels of cholesterol in the blood; this quantity is approved by Regulation 432/2012 of the European Commission. One capsule of Cardiol® Forte provides 10 mg of monacolin K.
Polyphenols in olive oil such as hydroxytyrosol help to protect blood lipids from oxidative stress. To benefit from this effect it is necessary to take 5 mg of hydroxytyrosol, quantitative approved by Regulation 432/2012 of the European Commission (one capsule of Cardiol® Forte supplies 5 mg of hydroxytyrosol).
Coenzyme Q10 is a fundamental oxidative reduction agent for the optimization of cellular energy production (in the form of adenosine triphosphate, ATP).
When taking monacolin K from fermented red rice preparations it is advisable to combine the supplement with coenzyme Q10. In fact, one capsule of Cardiol® Forte provides 100 mg of coenzyme Q10, one of the highest contents available on the market today.
Folic acid and vitamin B12 support the regular functioning of the homocysteine metabolism.
Vitamin E contributes to the protection of cells from oxidative stress as it acts as a neutralizer of free radicals.
The piperine, present in the extract of Piper nigrum, favors the absorption of all the nutrients, in particular of coenzyme Q10.
* Note Values calculated on a single administration
Following are some links of the articles related to the clinical studies carried out on the hydroxytyrosol molecule which would seem to have cardioprotective effects, as it is able to inhibit the expression of two genes (GRP78 and CHOP) that code for proteins directly involved in ischemia and hypoxia of myocardial tissue.
Furthermore, this molecule has a beneficial effect both for the prevention and for the course of atherosclerosis, supporting endothelial function, reducing oxidative stress and increasing HDL levels (the high-density lipoproteins that make up the so-called "good" cholesterol) . Hydroxytyrosol may also inhibit platelet aggregation. For these reasons it is a very useful component for the prevention of cardiovascular diseases.
Sesquiterpene (E) -beta-caryophyllene (BCP) hydrocarbon is a naturally occurring compound found in various plant species, including Piper nigrum. This compound in addition to possessing anxiolytic and antidepressive properties as it can selectively bind the cannabinoid CB2 receptor, has strong antioxidant properties, preventing lipid oxidative damage and improving the activity of the enzyme glutathione peroxidase, involved in the prevention of atherosclerosis.
The lipid-lowering action exerted by the BCP is linked to the ability of the aforementioned compound to reduce ROS (reactive oxygen species). It seems that elevated levels of ROS are associated with a hypothesis of HMG-CoA reductase, a key enzyme of endogenous cholesterol biosynthesis. This action is fundamental because the inflammatory response is precisely linked to a higher expression of HMG-CoA reductase. The activation of the CB2 receptor by BCP then causes a reduction in the release of the mediators of the inflammatory process. It also appears that BCP is a receptor ligand activated by peroxisome proliferators (PPAR-alpha). This receptor behaves as a transcription factor and is involved in the expression of genes encoding proteins that take part in the process of beta-oxidation of fatty acids, triglycerides and HDL metabolism. The activation of this receptor would result in a reduction of bad cholesterol (LDL) and triglycerides, as well as an increase in HLD ("good" cholesterol).
Monacolin is a "statin-like" molecule contained in fermented red rice, which inhibits HMG-CoA reductase. Several scientific studies have shown that the association of monacolin and coenzyme Q10 has resulted in actual improvements in patients with lipid dyslipidemia.